Causes of neuropathic pain

A number of different conditions can cause neuropathic pain. Not everyone who suffers from these conditions will experience neuropathic pain. The list below shows some of the most common causes, based on whether the damaged nerves are located in the peripheral or central nervous system:

Causes of peripheral neuropathic pain Causes of central neuropathic pain
  • Diabetic neuropathy
  • Postherpetic neuralgia
  • HIV/AIDS
  • Cancer or its treatment
  • Repetitive strain injury
  • Trauma (e.g. surgery, amputation)
  • Trigeminal neuralgia
  • Nutritional deficiencies
  • Post-amputation pain (phantom limb pain)
  • Complex regional pain syndrome
  • Spinal cord injury
  • Stroke
  • Multiple sclerosis
  • Brain or spinal cancer
  • Complex regional pain syndrome
  • Parkinson's disease
The pain you experience may be the result of touch, changes in temperature, or when you move a part of your body. The type of pain that you experience with central neuropathic pain can vary greatly. Also, central neuropathic pain may or may not appear immediately, depending on the type of condition that caused it.


Peripheral neuropathic pain is caused by an injury or condition that has damaged the nerves located outside the brain and spinal cord.
Central neuropathic pain is caused by a wound, injury or disease to your central nervous system. Your central nervous system is made up of your brain and your spinal cord.
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